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Genetic Polymorphism & Drug Effects

Potential consequences of administering the same dose of a medication to individuals with different drug-metabolism genotypes and different drug-receptor genotypes.

Translating Functional Genomics into Rational Therapeutics. Evans and Relling, Science, 1999, 487-491

 Genome Analysis

Entrez Genomes - whole genomes of over 1000 organisms. The genomes represent both completely sequenced organisms and those for which sequencing is in progress. All three main domains of life - bacteria, archaea, and eukaryota - are represented, as well as many viruses, phages, viroids, plasmids, and organelles.. Entrez Genomes provides graphical overviews of complete genomes/chromosomes and the ability to explore regions of interest in progressively greater detail.
COGs - Clusters of Orthologous Groups - a natural system of gene families from complete genomes. Clusters of Orthologous Groups (COGs) were delineated by comparing protein sequences encoded in 43 complete genomes, representing 30 major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain.
Map Viewer - shows integrated views of chromosome maps for many organisms, including human and numerous other vertebrates, invertebrates, fungi, protozoa, and plants. Map Viewer is used to view assembled genomes (either draft or complete) and is a valuable tool for the identification and localization of genes and other biological features. Multiple map displays are aligned based on shared marker and gene names when available, and sequence map displays are based on a common sequence coordinate system. Sequence data for chromosome regions of interest can be downloaded, biological annotations can be viewed in graphical format and/or downloaded in tabular format, and gene models can be manipulated in the associated ModelMaker tool.
SKY/M-FISH & CGH Database - The NCI and NCBI SKY/M-FISH and CGH Database is a repository of publicly submitted data from Spectral Karyotyping (SKY), Multiplex Fluorescence In Situ Hybridization (M-FISH), and Comparative Genomic Hybridization (CGH), which are complementary fluorescent molecular cytogenetic techniques. SKY/M-FISH permits the simultaneous visualization of each human or mouse chromosome in a different color, facilitating the identification of chromosomal aberrations; CGH can be used to generate a map of DNA copy number changes in tumor genomes. Collaborative project with the National Cancer Institute. ( data submission instructions...)

 

PROBABILITY OF EXPRESSION (POE)
An approach to the analysis of gene expression microarrays
using three-component mixtures



 

 

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